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| Human Alpha-1-antitrypsin (aa 25-375) |
| AAT Swiss Prot# | | P01009 |
| AAT Protein names | | Alpha-1-antitrypsin (Alpha-1 protease inhibitor) (Alpha-1-antiproteinase) [Cleaved into: Short peptide from AAT (SPAAT)] |
| AAT Gene names | | SERPINA1 (AAT) (PI) (PRO0684) (PRO2209) |
| Organism | | Human |
| AAT Entry name | | A1AT_HUMAN |
| AAT Codon optimized cDNA(gene) Clone |
| AAT Cat # | | RPE0693 |
| Tag | | AAT contains A 6x histidine tag |
| AAT Formulation | | Liquid |
| AAT Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| AAT Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant AAT Protein |
| AAT Cat # | | PE0693 |
| AAT Source | | recombinant |
| AAT Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| AAT Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| AAT Activity | | N/A |
| Tag | | AAT Contains A 6x histidine tag |
| AAT Formulation | | Liquid |
| AAT Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant AAT Products | | For pricing and availability Click Here >>> |
| AAT family | | Serpin family |
| AAT Subcellular locations | | Secreted. Secreted > extracellular space > extracellular matrix. |
| AAT FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.; FUNCTION: Short peptide from AAT (SPAAT) is a reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE). |
| AAT Sequence | | DDBJ | EMBL | GenBank |
| AAT 3D structure | | ModBase |
| AAT interaction | | STRING |
| AAT Proteomic | | PRIDE |
| AAT Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| AAT Organism specific | | CTD | MGI |
| AAT Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| AAT Gene expression | | Bgee | ArrayExpress | Genevestigator |
| AAT Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |