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Human Alpha-1-antitrypsin (aa 25-375)
AAT Swiss Prot#
P01009
AAT Protein names
Alpha-1-antitrypsin (Alpha-1 protease inhibitor) (Alpha-1-antiproteinase) [Cleaved into: Short peptide from AAT (SPAAT)]
AAT Gene names
SERPINA1 (AAT) (PI) (PRO0684) (PRO2209)
Organism
Human
AAT Entry name
A1AT_HUMAN
AAT Codon optimized cDNA(gene) Clone
AAT Cat #
RPE0693
Tag
AAT contains A 6x histidine tag
AAT Formulation
Liquid
AAT Storage
Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
AAT Applications
Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant AAT Protein
AAT Cat #
PE0693
AAT Source
recombinant
AAT Applications
Western Blot, SDS-Page or may be used for other applications determined by user
AAT Purity
>90%, as determined by SDS-PAGE under reducing conditions
AAT Activity
N/A
Tag
AAT Contains A 6x histidine tag
AAT Formulation
Liquid
AAT Storage
;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
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AAT family
Serpin family
AAT Subcellular locations
Secreted. Secreted > extracellular space > extracellular matrix.
AAT FUNCTION According to UniProtKB Swiss Prot
FUNCTION: Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.; FUNCTION: Short peptide from AAT (SPAAT) is a reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).
AAT Sequence
DDBJ EMBL GenBank
AAT 3D structure
ModBase
AAT interaction
STRING
AAT Proteomic
PRIDE
AAT Genome annotation
Ensembl GeneID KEGG UCSC
AAT Organism specific
CTD MGI
AAT Phylogenomics
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
AAT Gene expression
Bgee ArrayExpress Genevestigator
AAT Family and domain
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY