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Human JMJD6 (aa 141–305)

PTDSR Swiss Prot#

Q6NYC1

PTDSR Protein names

JMJD6 (KIAA0585) (PTDSR)

PTDSR Gene names

PTDSR

Organism

Human

PTDSR Entry name

JMJD6_HUMAN

PTDSR Codon optimized cDNA(gene) Clone

PTDSR Cat #

RPE0681

Tag

PTDSR contains A 6x histidine tag

PTDSR Formulation

Liquid

PTDSR Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

PTDSR Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant PTDSR Protein

PTDSR Cat #

PE0681

PTDSR Source

recombinant

PTDSR Applications

Western Blot, SDS-Page or may be used for other applications determined by user

PTDSR Purity

>90%, as determined by SDS-PAGE under reducing conditions

PTDSR Activity

N/A

Tag

PTDSR Contains A 6x histidine tag

PTDSR Formulation

Liquid

PTDSR Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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PTDSR family

JMJD6 family

PTDSR Subcellular locations

Nucleus > nucleoplasm. Nucleus > nucleolus.

PTDSR FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as a RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses.

PTDSR Sequence

DDBJ

EMBL

GenBank

PTDSR 3D structure

ModBase

PTDSR interaction

STRING

PTDSR Proteomic

PRIDE

PTDSR Genome annotation

Ensembl

GeneID

KEGG

UCSC

PTDSR Organism specific

CTD

MGI

PTDSR Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

PTDSR Gene expression

Bgee

ArrayExpress

Genevestigator

PTDSR Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY