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Human Retinoblastoma-associated protein (aa 373–771)

RB1 Swiss Prot#

P06400

RB1 Protein names

Retinoblastoma-associated protein (pRb) (Rb) (pp110) (p105-Rb)

RB1 Gene names

RB1

Organism

Human

RB1 Entry name

RB_HUMAN

RB1 Codon optimized cDNA(gene) Clone

RB1 Cat #

RPE0673

Tag

RB1 contains A 6x histidine tag

RB1 Formulation

Liquid

RB1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

RB1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant RB1 Protein

RB1 Cat #

PE0673

RB1 Source

recombinant

RB1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

RB1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

RB1 Activity

N/A

Tag

RB1 Contains A 6x histidine tag

RB1 Formulation

Liquid

RB1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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RB1 family

Retinoblastoma protein (RB) family

RB1 Subcellular locations

Nucleus.

RB1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity.

RB1 Sequence

DDBJ

EMBL

GenBank

RB1 3D structure

ModBase

RB1 interaction

STRING

RB1 Proteomic

PRIDE

RB1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

RB1 Organism specific

CTD

MGI

RB1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

RB1 Gene expression

Bgee

ArrayExpress

Genevestigator

RB1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY