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Human Lysosomal acid lipase cholesteryl ester hydrolase (aa 22–399)
LIPA Swiss Prot#
P38571
LIPA Protein names
Lysosomal acid lipase/cholesteryl ester hydrolase (LAL) (Acid cholesteryl ester hydrolase) (EC 3.1.1.13) (Sterol esterase) (Lipase A) (Cholesteryl esterase)
LIPA Gene names
LIPA
Organism
Human
LIPA Entry name
LICH_HUMAN
LIPA Codon optimized cDNA(gene) Clone
LIPA Cat #
RPE0671
Tag
LIPA contains A 6x histidine tag
LIPA Formulation
Liquid
LIPA Storage
Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
LIPA Applications
Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant LIPA Protein
LIPA Cat #
PE0671
LIPA Source
recombinant
LIPA Applications
Western Blot, SDS-Page or may be used for other applications determined by user
LIPA Purity
>90%, as determined by SDS-PAGE under reducing conditions
LIPA Activity
N/A
Tag
LIPA Contains A 6x histidine tag
LIPA Formulation
Liquid
LIPA Storage
;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
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LIPA family
AB hydrolase superfamily, Lipase family
LIPA Subcellular locations
Lysosome.
LIPA FUNCTION According to UniProtKB Swiss Prot
FUNCTION: Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor-mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation.
LIPA Sequence
DDBJ EMBL GenBank
LIPA 3D structure
ModBase
LIPA interaction
STRING
LIPA Proteomic
PRIDE
LIPA Genome annotation
Ensembl GeneID KEGG UCSC
LIPA Organism specific
CTD MGI
LIPA Phylogenomics
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
LIPA Gene expression
Bgee ArrayExpress Genevestigator
LIPA Family and domain
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY