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Human Protein Wnt-5a (aa 62–380)
WNT5A Swiss Prot#
P41221
WNT5A Protein names
Protein Wnt-5a
WNT5A Gene names
WNT5A
Organism
Human
WNT5A Entry name
WNT5A_HUMAN
WNT5A Codon optimized cDNA(gene) Clone
WNT5A Cat #
RPE0655
Tag
WNT5A contains A 6x histidine tag
WNT5A Formulation
Liquid
WNT5A Storage
Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
WNT5A Applications
Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant WNT5A Protein
WNT5A Cat #
PE0655
WNT5A Source
recombinant
WNT5A Applications
Western Blot, SDS-Page or may be used for other applications determined by user
WNT5A Purity
>90%, as determined by SDS-PAGE under reducing conditions
WNT5A Activity
N/A
Tag
WNT5A Contains A 6x histidine tag
WNT5A Formulation
Liquid
WNT5A Storage
;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
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WNT5A family
Wnt family
WNT5A Subcellular locations
Secreted > extracellular space > extracellular matrix.
WNT5A FUNCTION According to UniProtKB Swiss Prot
FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.
WNT5A Sequence
DDBJ EMBL GenBank
WNT5A 3D structure
ModBase
WNT5A interaction
STRING
WNT5A Proteomic
PRIDE
WNT5A Genome annotation
Ensembl GeneID KEGG UCSC
WNT5A Organism specific
CTD MGI
WNT5A Phylogenomics
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
WNT5A Gene expression
Bgee ArrayExpress Genevestigator
WNT5A Family and domain
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY