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Human E3 ubiquitin-protein ligase CBL (aa 46–357)

CBL2 Swiss Prot#

P22681

CBL2 Protein names

E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto-oncogene) (RING finger protein 55)

CBL2 Gene names

CBL (CBL2) (RNF55)

Organism

Human

CBL2 Entry name

CBL_HUMAN

CBL2 Codon optimized cDNA(gene) Clone

CBL2 Cat #

RPE0583

Tag

CBL2 contains A 6x histidine tag

CBL2 Formulation

Liquid

CBL2 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

CBL2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant CBL2 Protein

CBL2 Cat #

PE0583

CBL2 Source

recombinant

CBL2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

CBL2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

CBL2 Activity

N/A

Tag

CBL2 Contains A 6x histidine tag

CBL2 Formulation

Liquid

CBL2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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CBL2 family

-

CBL2 Subcellular locations

Cytoplasm.

CBL2 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling. Essential for osteoclastic bone resorption. The Tyr-731 phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function.

CBL2 Sequence

DDBJ

EMBL

GenBank

CBL2 3D structure

ModBase

CBL2 interaction

STRING

CBL2 Proteomic

PRIDE

CBL2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

CBL2 Organism specific

CTD

MGI

CBL2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

CBL2 Gene expression

Bgee

ArrayExpress

Genevestigator

CBL2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY