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Human Cell division protein kinase 4 (aa 6–295)

CDK4 Swiss Prot#

P11802

CDK4 Protein names

Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3)

CDK4 Gene names

CDK4

Organism

Human

CDK4 Entry name

CDK4_HUMAN

CDK4 Codon optimized cDNA(gene) Clone

CDK4 Cat #

RPE0577

Tag

CDK4 contains A 6x histidine tag

CDK4 Formulation

Liquid

CDK4 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

CDK4 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant CDK4 Protein

CDK4 Cat #

PE0577

CDK4 Source

recombinant

CDK4 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

CDK4 Purity

>90%, as determined by SDS-PAGE under reducing conditions

CDK4 Activity

N/A

Tag

CDK4 Contains A 6x histidine tag

CDK4 Formulation

Liquid

CDK4 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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CDK4 family

Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily

CDK4 Subcellular locations

Cytoplasm. Nucleus. Membrane.

CDK4 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

CDK4 Sequence

DDBJ

EMBL

GenBank

CDK4 3D structure

ModBase

CDK4 interaction

STRING

CDK4 Proteomic

PRIDE

CDK4 Genome annotation

Ensembl

GeneID

KEGG

UCSC

CDK4 Organism specific

CTD

MGI

CDK4 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

CDK4 Gene expression

Bgee

ArrayExpress

Genevestigator

CDK4 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY