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Human G1 S-specific cyclin-D1 (aa 1–295)

BCL1 Swiss Prot#

P24385

BCL1 Protein names

G1/S-specific cyclin-D1 (PRAD1 oncogene) (B-cell lymphoma 1 protein) (BCL-1) (BCL-1 oncogene)

BCL1 Gene names

CCND1 (BCL1) (PRAD1)

Organism

Human

BCL1 Entry name

CCND1_HUMAN

BCL1 Codon optimized cDNA(gene) Clone

BCL1 Cat #

RPE0570

Tag

BCL1 contains A 6x histidine tag

BCL1 Formulation

Liquid

BCL1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

BCL1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant BCL1 Protein

BCL1 Cat #

PE0570

BCL1 Source

recombinant

BCL1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

BCL1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

BCL1 Activity

N/A

Tag

BCL1 Contains A 6x histidine tag

BCL1 Formulation

Liquid

BCL1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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BCL1 family

Cyclin family, Cyclin D subfamily

BCL1 Subcellular locations

Nucleus. Cytoplasm. Membrane.

BCL1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

BCL1 Sequence

DDBJ

EMBL

GenBank

BCL1 3D structure

ModBase

BCL1 interaction

STRING

BCL1 Proteomic

PRIDE

BCL1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

BCL1 Organism specific

CTD

MGI

BCL1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

BCL1 Gene expression

Bgee

ArrayExpress

Genevestigator

BCL1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY