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Human Tyrosine-protein kinase SYK (aa 371–631)

SYK Swiss Prot#

P43405

SYK Protein names

Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase)

SYK Gene names

SYK

Organism

Human

SYK Entry name

KSYK_HUMAN

SYK Codon optimized cDNA(gene) Clone

SYK Cat #

RPE0530

Tag

SYK contains A 6x histidine tag

SYK Formulation

Liquid

SYK Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

SYK Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant SYK Protein

SYK Cat #

PE0530

SYK Source

recombinant

SYK Applications

Western Blot, SDS-Page or may be used for other applications determined by user

SYK Purity

>90%, as determined by SDS-PAGE under reducing conditions

SYK Activity

N/A

Tag

SYK Contains A 6x histidine tag

SYK Formulation

Liquid

SYK Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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SYK family

Protein kinase superfamily, Tyr protein kinase family, SYK/ZAP-70 subfamily

SYK Subcellular locations

-

SYK FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Positive effector of BCR-stimulated responses. Couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C-gamma-dependent pathway, when phosphorylated on Tyr-348 and Tyr-352. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion (By similarity). Phosphorylates USP25 and regulates its intracellular levels.

SYK Sequence

DDBJ

EMBL

GenBank

SYK 3D structure

ModBase

SYK interaction

STRING

SYK Proteomic

PRIDE

SYK Genome annotation

Ensembl

GeneID

KEGG

UCSC

SYK Organism specific

CTD

MGI

SYK Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

SYK Gene expression

Bgee

ArrayExpress

Genevestigator

SYK Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY