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Human 3-hydroxyacyl-CoA dehydrogenase type-2 (aa 2–261)

ERAB Swiss Prot#

Q99714

ERAB Protein names

3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (3-hydroxyacyl-CoA dehydrogenase type II) (Type II HADH) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (17-beta-hydroxysteroid dehydrogenase 10) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Short-chain type dehydrogenase/reductase XH98G2)

ERAB Gene names

HSD17B10 (ERAB) (HADH2) (MRPP2) (SCHAD) (XH98G2)

Organism

Human

ERAB Entry name

HCD2_HUMAN

ERAB Codon optimized cDNA(gene) Clone

ERAB Cat #

RPE0526

Tag

ERAB contains A 6x histidine tag

ERAB Formulation

Liquid

ERAB Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

ERAB Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant ERAB Protein

ERAB Cat #

PE0526

ERAB Source

recombinant

ERAB Applications

Western Blot, SDS-Page or may be used for other applications determined by user

ERAB Purity

>90%, as determined by SDS-PAGE under reducing conditions

ERAB Activity

N/A

Tag

ERAB Contains A 6x histidine tag

ERAB Formulation

Liquid

ERAB Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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ERAB family

Short-chain dehydrogenases/reductases (SDR) family

ERAB Subcellular locations

Mitochondrion.

ERAB FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD).

ERAB Sequence

DDBJ

EMBL

GenBank

ERAB 3D structure

ModBase

ERAB interaction

STRING

ERAB Proteomic

PRIDE

ERAB Genome annotation

Ensembl

GeneID

KEGG

UCSC

ERAB Organism specific

CTD

MGI

ERAB Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

ERAB Gene expression

Bgee

ArrayExpress

Genevestigator

ERAB Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY