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Human Focal adhesion kinase 1 (aa 422–680)

FAK Swiss Prot#

Q05397

FAK Protein names

Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (pp125FAK) (Protein-tyrosine kinase 2)

FAK Gene names

PTK2 (FAK) (FAK1)

Organism

Human

FAK Entry name

FAK1_HUMAN

FAK Codon optimized cDNA(gene) Clone

FAK Cat #

RPE0522

Tag

FAK contains A 6x histidine tag

FAK Formulation

Liquid

FAK Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

FAK Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant FAK Protein

FAK Cat #

PE0522

FAK Source

recombinant

FAK Applications

Western Blot, SDS-Page or may be used for other applications determined by user

FAK Purity

>90%, as determined by SDS-PAGE under reducing conditions

FAK Activity

N/A

Tag

FAK Contains A 6x histidine tag

FAK Formulation

Liquid

FAK Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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FAK family

Protein kinase superfamily, Tyr protein kinase family, FAK subfamily

FAK Subcellular locations

Cell junction > focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

FAK FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Microtubule-induced dephosphorylation at Tyr-397 is crucial for the induction of focal adhesion disassembly. Plays a potential role in oncogenic transformations resulting in increased kinase activity.

FAK Sequence

DDBJ

EMBL

GenBank

FAK 3D structure

ModBase

FAK interaction

STRING

FAK Proteomic

PRIDE

FAK Genome annotation

Ensembl

GeneID

KEGG

UCSC

FAK Organism specific

CTD

MGI

FAK Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

FAK Gene expression

Bgee

ArrayExpress

Genevestigator

FAK Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY