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| Human Serine-protein kinase ATM (aa 2712–2962) |
| ATM Swiss Prot# | | Q13315 |
| ATM Protein names | | Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T, mutated) |
| ATM Gene names | | ATM |
| Organism | | Human |
| ATM Entry name | | ATM_HUMAN |
| ATM Codon optimized cDNA(gene) Clone |
| ATM Cat # | | RPE0511 |
| Tag | | ATM contains A 6x histidine tag |
| ATM Formulation | | Liquid |
| ATM Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| ATM Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant ATM Protein |
| ATM Cat # | | PE0511 |
| ATM Source | | recombinant |
| ATM Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| ATM Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| ATM Activity | | N/A |
| Tag | | ATM Contains A 6x histidine tag |
| ATM Formulation | | Liquid |
| ATM Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant ATM Products | | For pricing and availability Click Here >>> |
| ATM family | | PI3/PI4-kinase family, ATM subfamily |
| ATM Subcellular locations | | Nucleus. Cytoplasmic vesicle. |
| ATM FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. |
| ATM Sequence | | DDBJ | EMBL | GenBank |
| ATM 3D structure | | ModBase |
| ATM interaction | | STRING |
| ATM Proteomic | | PRIDE |
| ATM Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| ATM Organism specific | | CTD | MGI |
| ATM Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| ATM Gene expression | | Bgee | ArrayExpress | Genevestigator |
| ATM Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
