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Human Glucocorticoid receptor (aa 528–777)

GRL Swiss Prot#

P04150

GRL Protein names

Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1)

GRL Gene names

NR3C1 (GRL)

Organism

Human

GRL Entry name

GCR_HUMAN

GRL Codon optimized cDNA(gene) Clone

GRL Cat #

RPE0509

Tag

GRL contains A 6x histidine tag

GRL Formulation

Liquid

GRL Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

GRL Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant GRL Protein

GRL Cat #

PE0509

GRL Source

recombinant

GRL Applications

Western Blot, SDS-Page or may be used for other applications determined by user

GRL Purity

>90%, as determined by SDS-PAGE under reducing conditions

GRL Activity

N/A

Tag

GRL Contains A 6x histidine tag

GRL Formulation

Liquid

GRL Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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GRL family

Nuclear hormone receptor family, NR3 subfamily

GRL Subcellular locations

Cytoplasm. Nucleus. Nucleus.

GRL FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation (By similarity).

GRL Sequence

DDBJ

EMBL

GenBank

GRL 3D structure

ModBase

GRL interaction

STRING

GRL Proteomic

PRIDE

GRL Genome annotation

Ensembl

GeneID

KEGG

UCSC

GRL Organism specific

CTD

MGI

GRL Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

GRL Gene expression

Bgee

ArrayExpress

Genevestigator

GRL Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY