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Human Apoptosis regulator Bcl-2 (aa 1–212)

BCL2 Swiss Prot#

P10415

BCL2 Protein names

Apoptosis regulator Bcl-2

BCL2 Gene names

BCL2

Organism

Human

BCL2 Entry name

BCL2_HUMAN

BCL2 Codon optimized cDNA(gene) Clone

BCL2 Cat #

RPE0497

Tag

BCL2 contains A 6x histidine tag

BCL2 Formulation

Liquid

BCL2 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

BCL2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant BCL2 Protein

BCL2 Cat #

PE0497

BCL2 Source

recombinant

BCL2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

BCL2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

BCL2 Activity

N/A

Tag

BCL2 Contains A 6x histidine tag

BCL2 Formulation

Liquid

BCL2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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BCL2 family

Bcl-2 family

BCL2 Subcellular locations

Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.

BCL2 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).

BCL2 Sequence

DDBJ

EMBL

GenBank

BCL2 3D structure

ModBase

BCL2 interaction

STRING

BCL2 Proteomic

PRIDE

BCL2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

BCL2 Organism specific

CTD

MGI

BCL2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

BCL2 Gene expression

Bgee

ArrayExpress

Genevestigator

BCL2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY