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Human Multidrug resistance-associated protein 1 (aa 1293–1527)

MRP Swiss Prot#

P33527

MRP Protein names

Multidrug resistance-associated protein 1 (ATP-binding cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter)

MRP Gene names

ABCC1 (MRP) (MRP1)

Organism

Human

MRP Entry name

MRP1_HUMAN

MRP Codon optimized cDNA(gene) Clone

MRP Cat #

RPE0495

Tag

MRP contains A 6x histidine tag

MRP Formulation

Liquid

MRP Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

MRP Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant MRP Protein

MRP Cat #

PE0495

MRP Source

recombinant

MRP Applications

Western Blot, SDS-Page or may be used for other applications determined by user

MRP Purity

>90%, as determined by SDS-PAGE under reducing conditions

MRP Activity

N/A

Tag

MRP Contains A 6x histidine tag

MRP Formulation

Liquid

MRP Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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MRP family

ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily

MRP Subcellular locations

Cell membrane; Multi-pass membrane protein.

MRP FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.

MRP Sequence

DDBJ

EMBL

GenBank

MRP 3D structure

ModBase

MRP interaction

STRING

MRP Proteomic

PRIDE

MRP Genome annotation

Ensembl

GeneID

KEGG

UCSC

MRP Organism specific

CTD

MGI

MRP Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

MRP Gene expression

Bgee

ArrayExpress

Genevestigator

MRP Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY