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Human Poly (aa 788–1014)

ADPRT Swiss Prot#

P09874

ADPRT Protein names

Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADPRT) (NAD(+) ADP-ribosyltransferase 1) (Poly[ADP-ribose] synthetase 1)

ADPRT Gene names

PARP1 (ADPRT) (PPOL)

Organism

Human

ADPRT Entry name

PARP1_HUMAN

ADPRT Codon optimized cDNA(gene) Clone

ADPRT Cat #

RPE0489

Tag

ADPRT contains A 6x histidine tag

ADPRT Formulation

Liquid

ADPRT Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

ADPRT Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant ADPRT Protein

ADPRT Cat #

PE0489

ADPRT Source

recombinant

ADPRT Applications

Western Blot, SDS-Page or may be used for other applications determined by user

ADPRT Purity

>90%, as determined by SDS-PAGE under reducing conditions

ADPRT Activity

N/A

Tag

ADPRT Contains A 6x histidine tag

ADPRT Formulation

Liquid

ADPRT Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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ADPRT family

-

ADPRT Subcellular locations

Nucleus.

ADPRT FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150.

ADPRT Sequence

DDBJ

EMBL

GenBank

ADPRT 3D structure

ModBase

ADPRT interaction

STRING

ADPRT Proteomic

PRIDE

ADPRT Genome annotation

Ensembl

GeneID

KEGG

UCSC

ADPRT Organism specific

CTD

MGI

ADPRT Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

ADPRT Gene expression

Bgee

ArrayExpress

Genevestigator

ADPRT Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY