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Human Breast cancer type 1 susceptibility protein (aa 1641-1863)

RNF53 Swiss Prot#

P38398

RNF53 Protein names

Breast cancer type 1 susceptibility protein (EC 6.3.2.-) (RING finger protein 53)

RNF53 Gene names

BRCA1 (RNF53)

Organism

Human

RNF53 Entry name

BRCA1_HUMAN

RNF53 Codon optimized cDNA(gene) Clone

RNF53 Cat #

RPE0485

Tag

RNF53 contains A 6x histidine tag

RNF53 Formulation

Liquid

RNF53 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

RNF53 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant RNF53 Protein

RNF53 Cat #

PE0485

RNF53 Source

recombinant

RNF53 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

RNF53 Purity

>90%, as determined by SDS-PAGE under reducing conditions

RNF53 Activity

N/A

Tag

RNF53 Contains A 6x histidine tag

RNF53 Formulation

Liquid

RNF53 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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RNF53 family

-

RNF53 Subcellular locations

Nucleus. Cytoplasm.

RNF53 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks.

RNF53 Sequence

DDBJ

EMBL

GenBank

RNF53 3D structure

ModBase

RNF53 interaction

STRING

RNF53 Proteomic

PRIDE

RNF53 Genome annotation

Ensembl

GeneID

KEGG

UCSC

RNF53 Organism specific

CTD

MGI

RNF53 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

RNF53 Gene expression

Bgee

ArrayExpress

Genevestigator

RNF53 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY