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Human Pro-neuregulin-1 membrane-bound isoform (aa 20–242)

GGF Swiss Prot#

Q02297

GGF Protein names

Pro-neuregulin-1, membrane-bound isoform (Pro-NRG1) [Cleaved into: Neuregulin-1 (Neu differentiation factor) (Heregulin) (HRG) (Breast cancer cell differentiation factor p45) (Acetylcholine receptor-inducing activity) (ARIA) (Sensory and motor neuron-derived factor) (Glial growth factor)]

GGF Gene names

NRG1 (GGF) (HGL) (HRGA) (NDF) (SMDF)

Organism

Human

GGF Entry name

NRG1_HUMAN

GGF Codon optimized cDNA(gene) Clone

GGF Cat #

RPE0483

Tag

GGF contains A 6x histidine tag

GGF Formulation

Liquid

GGF Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

GGF Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant GGF Protein

GGF Cat #

PE0483

GGF Source

recombinant

GGF Applications

Western Blot, SDS-Page or may be used for other applications determined by user

GGF Purity

>90%, as determined by SDS-PAGE under reducing conditions

GGF Activity

N/A

Tag

GGF Contains A 6x histidine tag

GGF Formulation

Liquid

GGF Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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GGF family

Neuregulin family

GGF Subcellular locations

Cell membrane; Single-pass type I membrane protein. Secreted. Nucleus. Membrane; Single-pass type I membrane protein.

GGF FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.

GGF Sequence

DDBJ

EMBL

GenBank

GGF 3D structure

ModBase

GGF interaction

STRING

GGF Proteomic

PRIDE

GGF Genome annotation

Ensembl

GeneID

KEGG

UCSC

GGF Organism specific

CTD

MGI

GGF Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

GGF Gene expression

Bgee

ArrayExpress

Genevestigator

GGF Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY