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Human Growth factor receptor-bound protein 2 (aa 1–217)

ASH Swiss Prot#

P62993

ASH Protein names

Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash)

ASH Gene names

GRB2 (ASH)

Organism

Human

ASH Entry name

GRB2_HUMAN

ASH Codon optimized cDNA(gene) Clone

ASH Cat #

RPE0475

Tag

ASH contains A 6x histidine tag

ASH Formulation

Liquid

ASH Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

ASH Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant ASH Protein

ASH Cat #

PE0475

ASH Source

recombinant

ASH Applications

Western Blot, SDS-Page or may be used for other applications determined by user

ASH Purity

>90%, as determined by SDS-PAGE under reducing conditions

ASH Activity

N/A

Tag

ASH Contains A 6x histidine tag

ASH Formulation

Liquid

ASH Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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ASH family

GRB2/sem-5/DRK family

ASH Subcellular locations

Golgi apparatus.

ASH FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.; FUNCTION: Isoform GRB3-3 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform GRB3-3 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.

ASH Sequence

DDBJ

EMBL

GenBank

ASH 3D structure

ModBase

ASH interaction

STRING

ASH Proteomic

PRIDE

ASH Genome annotation

Ensembl

GeneID

KEGG

UCSC

ASH Organism specific

CTD

MGI

ASH Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

ASH Gene expression

Bgee

ArrayExpress

Genevestigator

ASH Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY