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Human Fragile X mental retardation 1 protein (aa 419–632)

FMR1 Swiss Prot#

Q06787

FMR1 Protein names

Fragile X mental retardation 1 protein (Protein FMR-1) (FMRP)

FMR1 Gene names

FMR1

Organism

Human

FMR1 Entry name

FMR1_HUMAN

FMR1 Codon optimized cDNA(gene) Clone

FMR1 Cat #

RPE0473

Tag

FMR1 contains A 6x histidine tag

FMR1 Formulation

Liquid

FMR1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

FMR1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant FMR1 Protein

FMR1 Cat #

PE0473

FMR1 Source

recombinant

FMR1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

FMR1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

FMR1 Activity

N/A

Tag

FMR1 Contains A 6x histidine tag

FMR1 Formulation

Liquid

FMR1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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FMR1 family

FMR1 family

FMR1 Subcellular locations

Cytoplasm. Nucleus > nucleolus.

FMR1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Translation repressor. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression (By similarity). RNA-binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C).

FMR1 Sequence

DDBJ

EMBL

GenBank

FMR1 3D structure

ModBase

FMR1 interaction

STRING

FMR1 Proteomic

PRIDE

FMR1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

FMR1 Organism specific

CTD

MGI

FMR1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

FMR1 Gene expression

Bgee

ArrayExpress

Genevestigator

FMR1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY