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Human Von Hippel-Lindau disease tumor suppressor (aa 1–213)

VHL Swiss Prot#

P40337

VHL Protein names

Von Hippel-Lindau disease tumor suppressor (pVHL) (Protein G7)

VHL Gene names

VHL

Organism

Human

VHL Entry name

VHL_HUMAN

VHL Codon optimized cDNA(gene) Clone

VHL Cat #

RPE0471

Tag

VHL contains A 6x histidine tag

VHL Formulation

Liquid

VHL Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

VHL Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant VHL Protein

VHL Cat #

PE0471

VHL Source

recombinant

VHL Applications

Western Blot, SDS-Page or may be used for other applications determined by user

VHL Purity

>90%, as determined by SDS-PAGE under reducing conditions

VHL Activity

N/A

Tag

VHL Contains A 6x histidine tag

VHL Formulation

Liquid

VHL Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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VHL family

-

VHL Subcellular locations

Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Cytoplasm. Nucleus.

VHL FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases.

VHL Sequence

DDBJ

EMBL

GenBank

VHL 3D structure

ModBase

VHL interaction

STRING

VHL Proteomic

PRIDE

VHL Genome annotation

Ensembl

GeneID

KEGG

UCSC

VHL Organism specific

CTD

MGI

VHL Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

VHL Gene expression

Bgee

ArrayExpress

Genevestigator

VHL Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY