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Human Metalloproteinase inhibitor 1 (aa 24–207)

CLGI Swiss Prot#

P01033

CLGI Protein names

Metalloproteinase inhibitor 1 (Tissue inhibitor of metalloproteinases) (TIMP-1) (Erythroid-potentiating activity) (EPA) (Fibroblast collagenase inhibitor) (Collagenase inhibitor)

CLGI Gene names

TIMP1 (CLGI) (TIMP)

Organism

Human

CLGI Entry name

TIMP1_HUMAN

CLGI Codon optimized cDNA(gene) Clone

CLGI Cat #

RPE0466

Tag

CLGI contains A 6x histidine tag

CLGI Formulation

Liquid

CLGI Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

CLGI Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant CLGI Protein

CLGI Cat #

PE0466

CLGI Source

recombinant

CLGI Applications

Western Blot, SDS-Page or may be used for other applications determined by user

CLGI Purity

>90%, as determined by SDS-PAGE under reducing conditions

CLGI Activity

N/A

Tag

CLGI Contains A 6x histidine tag

CLGI Formulation

Liquid

CLGI Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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CLGI family

Protease inhibitor I35 (TIMP) family

CLGI Subcellular locations

Secreted.

CLGI FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14.

CLGI Sequence

DDBJ

EMBL

GenBank

CLGI 3D structure

ModBase

CLGI interaction

STRING

CLGI Proteomic

PRIDE

CLGI Genome annotation

Ensembl

GeneID

KEGG

UCSC

CLGI Organism specific

CTD

MGI

CLGI Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

CLGI Gene expression

Bgee

ArrayExpress

Genevestigator

CLGI Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY