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Human Breast cancer type 2 susceptibility protein (aa 2350–2545)

FACD Swiss Prot#

P51587

FACD Protein names

Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein)

FACD Gene names

BRCA2 (FACD) (FANCD1)

Organism

Human

FACD Entry name

BRCA2_HUMAN

FACD Codon optimized cDNA(gene) Clone

FACD Cat #

RPE0458

Tag

FACD contains A 6x histidine tag

FACD Formulation

Liquid

FACD Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

FACD Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant FACD Protein

FACD Cat #

PE0458

FACD Source

recombinant

FACD Applications

Western Blot, SDS-Page or may be used for other applications determined by user

FACD Purity

>90%, as determined by SDS-PAGE under reducing conditions

FACD Activity

N/A

Tag

FACD Contains A 6x histidine tag

FACD Formulation

Liquid

FACD Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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FACD family

-

FACD Subcellular locations

-

FACD FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures.

FACD Sequence

DDBJ

EMBL

GenBank

FACD 3D structure

ModBase

FACD interaction

STRING

FACD Proteomic

PRIDE

FACD Genome annotation

Ensembl

GeneID

KEGG

UCSC

FACD Organism specific

CTD

MGI

FACD Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

FACD Gene expression

Bgee

ArrayExpress

Genevestigator

FACD Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY