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Human Insulin-like growth factor 1 receptor (aa 741–935)

IGF1R Swiss Prot#

P08069

IGF1R Protein names

Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]

IGF1R Gene names

IGF1R

Organism

Human

IGF1R Entry name

IGF1R_HUMAN

IGF1R Codon optimized cDNA(gene) Clone

IGF1R Cat #

RPE0456

Tag

IGF1R contains A 6x histidine tag

IGF1R Formulation

Liquid

IGF1R Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

IGF1R Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant IGF1R Protein

IGF1R Cat #

PE0456

IGF1R Source

recombinant

IGF1R Applications

Western Blot, SDS-Page or may be used for other applications determined by user

IGF1R Purity

>90%, as determined by SDS-PAGE under reducing conditions

IGF1R Activity

N/A

Tag

IGF1R Contains A 6x histidine tag

IGF1R Formulation

Liquid

IGF1R Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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IGF1R family

Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily

IGF1R Subcellular locations

Membrane; Single-pass type I membrane protein.

IGF1R FUNCTION According to UniProtKB Swiss Prot

FUNCTION: This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.

IGF1R Sequence

DDBJ

EMBL

GenBank

IGF1R 3D structure

ModBase

IGF1R interaction

STRING

IGF1R Proteomic

PRIDE

IGF1R Genome annotation

Ensembl

GeneID

KEGG

UCSC

IGF1R Organism specific

CTD

MGI

IGF1R Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

IGF1R Gene expression

Bgee

ArrayExpress

Genevestigator

IGF1R Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY