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Human Insulin receptor (aa 763–956)

INSR Swiss Prot#

P06213

INSR Protein names

Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]

INSR Gene names

INSR

Organism

Human

INSR Entry name

INSR_HUMAN

INSR Codon optimized cDNA(gene) Clone

INSR Cat #

RPE0455

Tag

INSR contains A 6x histidine tag

INSR Formulation

Liquid

INSR Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

INSR Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant INSR Protein

INSR Cat #

PE0455

INSR Source

recombinant

INSR Applications

Western Blot, SDS-Page or may be used for other applications determined by user

INSR Purity

>90%, as determined by SDS-PAGE under reducing conditions

INSR Activity

N/A

Tag

INSR Contains A 6x histidine tag

INSR Formulation

Liquid

INSR Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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INSR family

Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily

INSR Subcellular locations

Membrane; Single-pass type I membrane protein.

INSR FUNCTION According to UniProtKB Swiss Prot

FUNCTION: This receptor binds insulin and has a tyrosine-protein kinase activity. Isoform Short has a higher affinity for insulin. Mediates the metabolic functions of insulin. Binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). Can activate PI3K either directly by binding to the p85 regulatory subunit, or indirectly via IRS1. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.

INSR Sequence

DDBJ

EMBL

GenBank

INSR 3D structure

ModBase

INSR interaction

STRING

INSR Proteomic

PRIDE

INSR Genome annotation

Ensembl

GeneID

KEGG

UCSC

INSR Organism specific

CTD

MGI

INSR Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

INSR Gene expression

Bgee

ArrayExpress

Genevestigator

INSR Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY