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Human Prostaglandin-H2 D-isomerase (aa 23–190)

PDS Swiss Prot#

P41222

PDS Protein names

Prostaglandin-H2 D-isomerase (EC 5.3.99.2) (Lipocalin-type prostaglandin-D synthase) (Glutathione-independent PGD synthetase) (Prostaglandin-D2 synthase) (PGD2 synthase) (PGDS2) (PGDS) (Beta-trace protein) (Cerebrin-28)

PDS Gene names

PTGDS (PDS)

Organism

Human

PDS Entry name

PTGDS_HUMAN

PDS Codon optimized cDNA(gene) Clone

PDS Cat #

RPE0449

Tag

PDS contains A 6x histidine tag

PDS Formulation

Liquid

PDS Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

PDS Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant PDS Protein

PDS Cat #

PE0449

PDS Source

recombinant

PDS Applications

Western Blot, SDS-Page or may be used for other applications determined by user

PDS Purity

>90%, as determined by SDS-PAGE under reducing conditions

PDS Activity

N/A

Tag

PDS Contains A 6x histidine tag

PDS Formulation

Liquid

PDS Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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PDS family

Calycin superfamily, Lipocalin family

PDS Subcellular locations

Rough endoplasmic reticulum. Nucleus membrane. Golgi apparatus. Cytoplasm > perinuclear region. Secreted.

PDS FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.

PDS Sequence

DDBJ

EMBL

GenBank

PDS 3D structure

ModBase

PDS interaction

STRING

PDS Proteomic

PRIDE

PDS Genome annotation

Ensembl

GeneID

KEGG

UCSC

PDS Organism specific

CTD

MGI

PDS Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

PDS Gene expression

Bgee

ArrayExpress

Genevestigator

PDS Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY