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Human Phosphatidylinositol 3-kinase regulatory subunit (aa 113–301)

GRB1 Swiss Prot#

P27986

GRB1 Protein names

Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85 subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K)

GRB1 Gene names

PIK3R1 (GRB1)

Organism

Human

GRB1 Entry name

P85A_HUMAN

GRB1 Codon optimized cDNA(gene) Clone

GRB1 Cat #

RPE0446

Tag

GRB1 contains A 6x histidine tag

GRB1 Formulation

Liquid

GRB1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

GRB1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant GRB1 Protein

GRB1 Cat #

PE0446

GRB1 Source

recombinant

GRB1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

GRB1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

GRB1 Activity

N/A

Tag

GRB1 Contains A 6x histidine tag

GRB1 Formulation

Liquid

GRB1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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GRB1 family

PI3K p85 subunit family

GRB1 Subcellular locations

-

GRB1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.

GRB1 Sequence

DDBJ

EMBL

GenBank

GRB1 3D structure

ModBase

GRB1 interaction

STRING

GRB1 Proteomic

PRIDE

GRB1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

GRB1 Organism specific

CTD

MGI

GRB1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

GRB1 Gene expression

Bgee

ArrayExpress

Genevestigator

GRB1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY