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| Human Protein DJ-1 (aa 1–189) |
| PARK7 Swiss Prot# | | Q99497 |
| PARK7 Protein names | | Protein DJ-1 (Oncogene DJ1) (Parkinson disease protein 7) |
| PARK7 Gene names | | PARK7 |
| Organism | | Human |
| PARK7 Entry name | | PARK7_HUMAN |
| PARK7 Codon optimized cDNA(gene) Clone |
| PARK7 Cat # | | RPE0444 |
| Tag | | PARK7 contains A 6x histidine tag |
| PARK7 Formulation | | Liquid |
| PARK7 Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| PARK7 Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant PARK7 Protein |
| PARK7 Cat # | | PE0444 |
| PARK7 Source | | recombinant |
| PARK7 Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| PARK7 Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| PARK7 Activity | | N/A |
| Tag | | PARK7 Contains A 6x histidine tag |
| PARK7 Formulation | | Liquid |
| PARK7 Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant PARK7 Products | | For pricing and availability Click Here >>> |
| PARK7 family | | Peptidase C56 family |
| PARK7 Subcellular locations | | Cytoplasm. Nucleus. Mitochondrion. |
| PARK7 FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: Protects cells against oxidative stress and cell death. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. May act as an atypical peroxiredoxin-like peroxidase that scavenges hydrogen peroxide. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective action against oxidative stress-induced apoptosis. Stabilizes NFE2L2 by preventing its association with KEAP1 and its subsequent ubiquitination. Binds to OTUD7B and inhibits its deubiquitinating activity. Enhances RELA nuclear translocation. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Required for correct mitochondrial morphology and function and for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses. Acts as a positive regulator of androgen receptor-dependent transcription. Prevents aggregation of SNCA. Plays a role in fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity. May function as a redox-sensitive chaperone. |
| PARK7 Sequence | | DDBJ | EMBL | GenBank |
| PARK7 3D structure | | ModBase |
| PARK7 interaction | | STRING |
| PARK7 Proteomic | | PRIDE |
| PARK7 Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| PARK7 Organism specific | | CTD | MGI |
| PARK7 Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| PARK7 Gene expression | | Bgee | ArrayExpress | Genevestigator |
| PARK7 Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
