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Human CSPG4 (aa 202–380)

MCSP Swiss Prot#

Q6UVK1

MCSP Protein names

CSPG4 (MCSP)

MCSP Gene names

MCSP

Organism

Human

MCSP Entry name

CSPG4_HUMAN

MCSP Codon optimized cDNA(gene) Clone

MCSP Cat #

RPE0440

Tag

MCSP contains A 6x histidine tag

MCSP Formulation

Liquid

MCSP Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

MCSP Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant MCSP Protein

MCSP Cat #

PE0440

MCSP Source

recombinant

MCSP Applications

Western Blot, SDS-Page or may be used for other applications determined by user

MCSP Purity

>90%, as determined by SDS-PAGE under reducing conditions

MCSP Activity

N/A

Tag

MCSP Contains A 6x histidine tag

MCSP Formulation

Liquid

MCSP Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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MCSP family

-

MCSP Subcellular locations

Apical cell membrane; Single-pass type I membrane protein; Extracellular side. Cell projection > lamellipodium membrane; Single-pass type I membrane protein; Extracellular side.

MCSP FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades.

MCSP Sequence

DDBJ

EMBL

GenBank

MCSP 3D structure

ModBase

MCSP interaction

STRING

MCSP Proteomic

PRIDE

MCSP Genome annotation

Ensembl

GeneID

KEGG

UCSC

MCSP Organism specific

CTD

MGI

MCSP Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

MCSP Gene expression

Bgee

ArrayExpress

Genevestigator

MCSP Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY