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Human DNA excision repair protein ERCC-6 (aa 519–695)

CSB Swiss Prot#

Q03468

CSB Protein names

DNA excision repair protein ERCC-6 (EC 3.6.1.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB)

CSB Gene names

ERCC6 (CSB)

Organism

Human

CSB Entry name

ERCC6_HUMAN

CSB Codon optimized cDNA(gene) Clone

CSB Cat #

RPE0437

Tag

CSB contains A 6x histidine tag

CSB Formulation

Liquid

CSB Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

CSB Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant CSB Protein

CSB Cat #

PE0437

CSB Source

recombinant

CSB Applications

Western Blot, SDS-Page or may be used for other applications determined by user

CSB Purity

>90%, as determined by SDS-PAGE under reducing conditions

CSB Activity

N/A

Tag

CSB Contains A 6x histidine tag

CSB Formulation

Liquid

CSB Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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CSB family

SNF2/RAD54 helicase family

CSB Subcellular locations

Nucleus.

CSB FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation. It recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to the at sites of RNA polymerase II-blocking lesions.

CSB Sequence

DDBJ

EMBL

GenBank

CSB 3D structure

ModBase

CSB interaction

STRING

CSB Proteomic

PRIDE

CSB Genome annotation

Ensembl

GeneID

KEGG

UCSC

CSB Organism specific

CTD

MGI

CSB Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

CSB Gene expression

Bgee

ArrayExpress

Genevestigator

CSB Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY