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| Human Cyclin-dependent kinase inhibitor 2A isoform 4 (aa 1–173) |
| CDKN2 Swiss Prot# | | Q8N726 |
| CDKN2 Protein names | | Cyclin-dependent kinase inhibitor 2A, isoform 4 (p14ARF) (p19ARF) |
| CDKN2 Gene names | | CDKN2A (CDKN2) (MLM) |
| Organism | | Human |
| CDKN2 Entry name | | CD2A2_HUMAN |
| CDKN2 Codon optimized cDNA(gene) Clone |
| CDKN2 Cat # | | RPE0434 |
| Tag | | CDKN2 contains A 6x histidine tag |
| CDKN2 Formulation | | Liquid |
| CDKN2 Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| CDKN2 Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant CDKN2 Protein |
| CDKN2 Cat # | | PE0434 |
| CDKN2 Source | | recombinant |
| CDKN2 Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| CDKN2 Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| CDKN2 Activity | | N/A |
| Tag | | CDKN2 Contains A 6x histidine tag |
| CDKN2 Formulation | | Liquid |
| CDKN2 Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant CDKN2 Products | | For pricing and availability Click Here >>> |
| CDKN2 family | | - |
| CDKN2 Subcellular locations | | Nucleus > nucleolus. Nucleus > nucleoplasm. |
| CDKN2 FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development. |
| CDKN2 Sequence | | DDBJ | EMBL | GenBank |
| CDKN2 3D structure | | ModBase |
| CDKN2 interaction | | STRING |
| CDKN2 Proteomic | | PRIDE |
| CDKN2 Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| CDKN2 Organism specific | | CTD | MGI |
| CDKN2 Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| CDKN2 Gene expression | | Bgee | ArrayExpress | Genevestigator |
| CDKN2 Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
