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Human Cyclin-dependent kinase inhibitor 1 (aa 2–164)

CAP20 Swiss Prot#

P38936

CAP20 Protein names

Cyclin-dependent kinase inhibitor 1 (p21) (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6)

CAP20 Gene names

CDKN1A (CAP20) (CDKN1) (CIP1) (MDA6) (PIC1) (SDI1) (WAF1)

Organism

Human

CAP20 Entry name

CDN1A_HUMAN

CAP20 Codon optimized cDNA(gene) Clone

CAP20 Cat #

RPE0427

Tag

CAP20 contains A 6x histidine tag

CAP20 Formulation

Liquid

CAP20 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

CAP20 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant CAP20 Protein

CAP20 Cat #

PE0427

CAP20 Source

recombinant

CAP20 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

CAP20 Purity

>90%, as determined by SDS-PAGE under reducing conditions

CAP20 Activity

N/A

Tag

CAP20 Contains A 6x histidine tag

CAP20 Formulation

Liquid

CAP20 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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CAP20 family

CDI family

CAP20 Subcellular locations

Cytoplasm. Nucleus.

CAP20 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.

CAP20 Sequence

DDBJ

EMBL

GenBank

CAP20 3D structure

ModBase

CAP20 interaction

STRING

CAP20 Proteomic

PRIDE

CAP20 Genome annotation

Ensembl

GeneID

KEGG

UCSC

CAP20 Organism specific

CTD

MGI

CAP20 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

CAP20 Gene expression

Bgee

ArrayExpress

Genevestigator

CAP20 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY