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Human Baculoviral IAP repeat-containing protein 5 (aa 1–142)

API4 Swiss Prot#

O15392

API4 Protein names

Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4)

API4 Gene names

BIRC5 (API4) (IAP4)

Organism

Human

API4 Entry name

BIRC5_HUMAN

API4 Codon optimized cDNA(gene) Clone

API4 Cat #

RPE0419

Tag

API4 contains A 6x histidine tag

API4 Formulation

Liquid

API4 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

API4 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant API4 Protein

API4 Cat #

PE0419

API4 Source

recombinant

API4 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

API4 Purity

>90%, as determined by SDS-PAGE under reducing conditions

API4 Activity

N/A

Tag

API4 Contains A 6x histidine tag

API4 Formulation

Liquid

API4 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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API4 family

IAP family

API4 Subcellular locations

Cytoplasm. Nucleus. Chromosome. Chromosome > centromere. Cytoplasm > cytoskeleton > spindle.

API4 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May play a role in neoplasia. May counteract a default induction of apoptosis in G2/M phase. Inhibitor of caspase-3 and caspase-7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.

API4 Sequence

DDBJ

EMBL

GenBank

API4 3D structure

ModBase

API4 interaction

STRING

API4 Proteomic

PRIDE

API4 Genome annotation

Ensembl

GeneID

KEGG

UCSC

API4 Organism specific

CTD

MGI

API4 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

API4 Gene expression

Bgee

ArrayExpress

Genevestigator

API4 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY