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Human CD59 glycoprotein (aa 26–102)

MIC11 Swiss Prot#

P13987

MIC11 Protein names

CD59 glycoprotein (Membrane attack complex inhibition factor) (MACIF) (MAC-inhibitory protein) (MAC-IP) (Protectin) (MEM43 antigen) (Membrane inhibitor of reactive lysis) (MIRL) (20 kDa homologous restriction factor) (HRF-20) (HRF20) (1F5 antigen) (CD antigen CD59)

MIC11 Gene names

CD59 (MIC11) (MIN1) (MIN2) (MIN3) (MSK21)

Organism

Human

MIC11 Entry name

CD59_HUMAN

MIC11 Codon optimized cDNA(gene) Clone

MIC11 Cat #

RPE0417

Tag

MIC11 contains A 6x histidine tag

MIC11 Formulation

Liquid

MIC11 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

MIC11 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant MIC11 Protein

MIC11 Cat #

PE0417

MIC11 Source

recombinant

MIC11 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

MIC11 Purity

>90%, as determined by SDS-PAGE under reducing conditions

MIC11 Activity

N/A

Tag

MIC11 Contains A 6x histidine tag

MIC11 Formulation

Liquid

MIC11 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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MIC11 family

-

MIC11 Subcellular locations

Cell membrane; Lipid-anchor > GPI-anchor. Secreted.

MIC11 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.; FUNCTION: The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.

MIC11 Sequence

DDBJ

EMBL

GenBank

MIC11 3D structure

ModBase

MIC11 interaction

STRING

MIC11 Proteomic

PRIDE

MIC11 Genome annotation

Ensembl

GeneID

KEGG

UCSC

MIC11 Organism specific

CTD

MGI

MIC11 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

MIC11 Gene expression

Bgee

ArrayExpress

Genevestigator

MIC11 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY