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Human Histone-lysine N-methyltransferase MLL (aa 3828–3949)

ALL1 Swiss Prot#

Q03164

ALL1 Protein names

Histone-lysine N-methyltransferase MLL (EC 2.1.1.43) (Zinc finger protein HRX) (ALL-1) (Trithorax-like protein) (Lysine N-methyltransferase 2A) (CXXC-type zinc finger protein 7) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]

ALL1 Gene names

MLL (ALL1) (CXXC7) (HRX) (HTRX) (KMT2A) (MLL1) (TRX1)

Organism

Human

ALL1 Entry name

MLL1_HUMAN

ALL1 Codon optimized cDNA(gene) Clone

ALL1 Cat #

RPE0413

Tag

ALL1 contains A 6x histidine tag

ALL1 Formulation

Liquid

ALL1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

ALL1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant ALL1 Protein

ALL1 Cat #

PE0413

ALL1 Source

recombinant

ALL1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

ALL1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

ALL1 Activity

N/A

Tag

ALL1 Contains A 6x histidine tag

ALL1 Formulation

Liquid

ALL1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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ALL1 family

Histone-lysine methyltransferase family, TRX/MLL subfamily

ALL1 Subcellular locations

Nucleus.

ALL1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis.

ALL1 Sequence

DDBJ

EMBL

GenBank

ALL1 3D structure

ModBase

ALL1 interaction

STRING

ALL1 Proteomic

PRIDE

ALL1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

ALL1 Organism specific

CTD

MGI

ALL1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

ALL1 Gene expression

Bgee

ArrayExpress

Genevestigator

ALL1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY