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Human Prolow-density lipoprotein receptor-related 1 (aa 4441–4544)

A2MR Swiss Prot#

Q07954

A2MR Protein names

Prolow-density lipoprotein receptor-related protein 1 (LRP) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)]

A2MR Gene names

LRP1 (A2MR) (APR)

Organism

Human

A2MR Entry name

LRP1_HUMAN

A2MR Codon optimized cDNA(gene) Clone

A2MR Cat #

RPE0407

Tag

A2MR contains A 6x histidine tag

A2MR Formulation

Liquid

A2MR Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

A2MR Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant A2MR Protein

A2MR Cat #

PE0407

A2MR Source

recombinant

A2MR Applications

Western Blot, SDS-Page or may be used for other applications determined by user

A2MR Purity

>90%, as determined by SDS-PAGE under reducing conditions

A2MR Activity

N/A

Tag

A2MR Contains A 6x histidine tag

A2MR Formulation

Liquid

A2MR Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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A2MR family

LDLR family

A2MR Subcellular locations

Cell membrane; Single-pass type I membrane protein. Membrane > coated pit. Cell membrane; Peripheral membrane protein; Extracellular side. Membrane > coated pit. Cytoplasm. Nucleus.

A2MR FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.

A2MR Sequence

DDBJ

EMBL

GenBank

A2MR 3D structure

ModBase

A2MR interaction

STRING

A2MR Proteomic

PRIDE

A2MR Genome annotation

Ensembl

GeneID

KEGG

UCSC

A2MR Organism specific

CTD

MGI

A2MR Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

A2MR Gene expression

Bgee

ArrayExpress

Genevestigator

A2MR Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY