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Mouse Endonuclease VIII-like 1 (aa 2-389)

Nei1 Swiss Prot#

Q8K4Q6

Nei1 Protein names

Endonuclease VIII-like 1 (Nei-like 1) (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase/AP lyase Neil1) (DNA-(apurinic or apyrimidinic site) lyase Neil1) (NEH1)

Nei1 Gene names

Neil1 (Nei1)

Organism

Mouse

Nei1 Entry name

NEIL1_MOUSE

Nei1 Codon optimized cDNA(gene) Clone

Nei1 Cat #

RPE0338

Tag

Nei1 contains A 6x histidine tag

Nei1 Formulation

Liquid

Nei1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Nei1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Nei1 Protein

Nei1 Cat #

PE0338

Nei1 Source

recombinant

Nei1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Nei1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Nei1 Activity

N/A

Tag

Nei1 Contains A 6x histidine tag

Nei1 Formulation

Liquid

Nei1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Nei1 family

FPG family

Nei1 Subcellular locations

Nucleus.

Nei1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches (By similarity).

Nei1 Sequence

DDBJ

EMBL

GenBank

Nei1 3D structure

ModBase

Nei1 interaction

STRING

Nei1 Proteomic

PRIDE

Nei1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Nei1 Organism specific

CTD

MGI

Nei1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Nei1 Gene expression

Bgee

ArrayExpress

Genevestigator

Nei1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY