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Mouse Growth factor receptor-bound protein 2 (aa 1-217)

Grb2 Swiss Prot#

Q60631

Grb2 Protein names

Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)

Grb2 Gene names

Grb2

Organism

Mouse

Grb2 Entry name

GRB2_MOUSE

Grb2 Codon optimized cDNA(gene) Clone

Grb2 Cat #

RPE0293

Tag

Grb2 contains A 6x histidine tag

Grb2 Formulation

Liquid

Grb2 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Grb2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Grb2 Protein

Grb2 Cat #

PE0293

Grb2 Source

recombinant

Grb2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Grb2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Grb2 Activity

N/A

Tag

Grb2 Contains A 6x histidine tag

Grb2 Formulation

Liquid

Grb2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Grb2 family

GRB2/sem-5/DRK family

Grb2 Subcellular locations

Golgi apparatus.

Grb2 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.; FUNCTION: Isoform GRB3-3 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform GRB3-3 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death (By similarity).

Grb2 Sequence

DDBJ

EMBL

GenBank

Grb2 3D structure

ModBase

Grb2 interaction

STRING

Grb2 Proteomic

PRIDE

Grb2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Grb2 Organism specific

CTD

MGI

Grb2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Grb2 Gene expression

Bgee

ArrayExpress

Genevestigator

Grb2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY