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Human Heparanase (aa 158-543)

HEP Swiss Prot#

Q9Y251

HEP Protein names

Heparanase (EC 3.2.-.-) (Heparanase-1) (Hpa1) (Endo-glucoronidase) [Cleaved into: Heparanase 8 kDa subunit; Heparanase 50 kDa subunit]

HEP Gene names

HPSE (HEP) (HPA) (HPA1) (HPR1) (HPSE1) (HSE1)

Organism

Human

HEP Entry name

HPSE_HUMAN

HEP Codon optimized cDNA(gene) Clone

HEP Cat #

RPE0267

Tag

HEP contains A 6x histidine tag

HEP Formulation

Liquid

HEP Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

HEP Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant HEP Protein

HEP Cat #

PE0267

HEP Source

recombinant

HEP Applications

Western Blot, SDS-Page or may be used for other applications determined by user

HEP Purity

>90%, as determined by SDS-PAGE under reducing conditions

HEP Activity

N/A

Tag

HEP Contains A 6x histidine tag

HEP Formulation

Liquid

HEP Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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HEP family

Glycosyl hydrolase 79 family

HEP Subcellular locations

Lysosome membrane; Peripheral membrane protein. Secreted.

HEP FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Endoglycosidase which is a cell surface and extracellular matrix-degrading enzyme. Cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Also implicated in the extravasation of leukocytes and tumor cell lines. Due to its contribution to metastasis and angiogenesis, it is considered to be a potential target for anti-cancer therapies.

HEP Sequence

DDBJ

EMBL

GenBank

HEP 3D structure

ModBase

HEP interaction

STRING

HEP Proteomic

PRIDE

HEP Genome annotation

Ensembl

GeneID

KEGG

UCSC

HEP Organism specific

CTD

MGI

HEP Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

HEP Gene expression

Bgee

ArrayExpress

Genevestigator

HEP Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY