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Human Importin subunit alpha-2 (aa 2-529)

RCH1 Swiss Prot#

P52292

RCH1 Protein names

Importin subunit alpha-2 (Karyopherin subunit alpha-2) (SRP1-alpha) (RAG cohort protein 1)

RCH1 Gene names

KPNA2 (RCH1) (SRP1)

Organism

Human

RCH1 Entry name

IMA2_HUMAN

RCH1 Codon optimized cDNA(gene) Clone

RCH1 Cat #

RPE0259

Tag

RCH1 contains A 6x histidine tag

RCH1 Formulation

Liquid

RCH1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

RCH1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant RCH1 Protein

RCH1 Cat #

PE0259

RCH1 Source

recombinant

RCH1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

RCH1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

RCH1 Activity

N/A

Tag

RCH1 Contains A 6x histidine tag

RCH1 Formulation

Liquid

RCH1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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RCH1 family

Importin alpha family

RCH1 Subcellular locations

Cytoplasm. Nucleus.

RCH1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

RCH1 Sequence

DDBJ

EMBL

GenBank

RCH1 3D structure

ModBase

RCH1 interaction

STRING

RCH1 Proteomic

PRIDE

RCH1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

RCH1 Organism specific

CTD

MGI

RCH1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

RCH1 Gene expression

Bgee

ArrayExpress

Genevestigator

RCH1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY