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| Human Large neutral amino acids transporter small subunit 1 (aa 1-507) |
| CD98LC Swiss Prot# | | Q01650 |
| CD98LC Protein names | | Large neutral amino acids transporter small subunit 1 (L-type amino acid transporter 1) (Solute carrier family 7 member 5) (y+ system cationic amino acid transporter) (4F2 light chain) (4F2 LC) (4F2LC) (CD98 light chain) (Integral membrane protein E16) (hLAT1) |
| CD98LC Gene names | | SLC7A5 (CD98LC) (LAT1) (MPE16) |
| Organism | | Human |
| CD98LC Entry name | | LAT1_HUMAN |
| CD98LC Codon optimized cDNA(gene) Clone |
| CD98LC Cat # | | RPE0246 |
| Tag | | CD98LC contains A 6x histidine tag |
| CD98LC Formulation | | Liquid |
| CD98LC Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| CD98LC Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant CD98LC Protein |
| CD98LC Cat # | | PE0246 |
| CD98LC Source | | recombinant |
| CD98LC Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| CD98LC Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| CD98LC Activity | | N/A |
| Tag | | CD98LC Contains A 6x histidine tag |
| CD98LC Formulation | | Liquid |
| CD98LC Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant CD98LC Products | | For pricing and availability Click Here >>> |
| CD98LC family | | Amino acid-polyamine-organocation (APC) superfamily, L-type amino acid transporter (LAT) (TC 2.A.3.8) family |
| CD98LC Subcellular locations | | Cytoplasm > cytosol. Apical cell membrane; Multi-pass membrane protein. |
| CD98LC FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Involved in cellular amino acid uptake. Acts as an amino acid exchanger. Involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Plays a role in neuronal cell proliferation (neurogenesis) in brain. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. May play an important role in high-grade gliomas. Mediates blood-to-retina L-leucine transport across the inner blood-retinal barrier which in turn may play a key role in maintaining large neutral amino acids as well as neurotransmitters in the neural retina. Acts as the major transporter of tyrosine in fibroblasts. |
| CD98LC Sequence | | DDBJ | EMBL | GenBank |
| CD98LC 3D structure | | ModBase |
| CD98LC interaction | | STRING |
| CD98LC Proteomic | | PRIDE |
| CD98LC Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| CD98LC Organism specific | | CTD | MGI |
| CD98LC Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| CD98LC Gene expression | | Bgee | ArrayExpress | Genevestigator |
| CD98LC Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
