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Human Telomeric repeat-binding factor 2 (aa 1-500)

TRBF2 Swiss Prot#

Q15554

TRBF2 Protein names

Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein)

TRBF2 Gene names

TERF2 (TRBF2) (TRF2)

Organism

Human

TRBF2 Entry name

TERF2_HUMAN

TRBF2 Codon optimized cDNA(gene) Clone

TRBF2 Cat #

RPE0242

Tag

TRBF2 contains A 6x histidine tag

TRBF2 Formulation

Liquid

TRBF2 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

TRBF2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant TRBF2 Protein

TRBF2 Cat #

PE0242

TRBF2 Source

recombinant

TRBF2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

TRBF2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

TRBF2 Activity

N/A

Tag

TRBF2 Contains A 6x histidine tag

TRBF2 Formulation

Liquid

TRBF2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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TRBF2 family

-

TRBF2 Subcellular locations

Nucleus. Chromosome > telomere.

TRBF2 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length.

TRBF2 Sequence

DDBJ

EMBL

GenBank

TRBF2 3D structure

ModBase

TRBF2 interaction

STRING

TRBF2 Proteomic

PRIDE

TRBF2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

TRBF2 Organism specific

CTD

MGI

TRBF2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

TRBF2 Gene expression

Bgee

ArrayExpress

Genevestigator

TRBF2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY