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Human Telomeric repeat-binding factor 1 (aa 2-438)

PIN2 Swiss Prot#

P54274

PIN2 Protein names

Telomeric repeat-binding factor 1 (TTAGGG repeat-binding factor 1) (NIMA-interacting protein 2) (Telomeric protein Pin2/TRF1)

PIN2 Gene names

TERF1 (PIN2) (TRBF1) (TRF) (TRF1)

Organism

Human

PIN2 Entry name

TERF1_HUMAN

PIN2 Codon optimized cDNA(gene) Clone

PIN2 Cat #

RPE0200

Tag

PIN2 contains A 6x histidine tag

PIN2 Formulation

Liquid

PIN2 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

PIN2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant PIN2 Protein

PIN2 Cat #

PE0200

PIN2 Source

recombinant

PIN2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

PIN2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

PIN2 Activity

N/A

Tag

PIN2 Contains A 6x histidine tag

PIN2 Formulation

Liquid

PIN2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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PIN2 family

-

PIN2 Subcellular locations

Nucleus. Cytoplasm > cytoskeleton > spindle. Chromosome > telomere.

PIN2 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.

PIN2 Sequence

DDBJ

EMBL

GenBank

PIN2 3D structure

ModBase

PIN2 interaction

STRING

PIN2 Proteomic

PRIDE

PIN2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

PIN2 Organism specific

CTD

MGI

PIN2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

PIN2 Gene expression

Bgee

ArrayExpress

Genevestigator

PIN2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY