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Human Keratin type I cytoskeletal 17 (aa 2-432)

KRT17 Swiss Prot#

Q04695

KRT17 Protein names

Keratin, type I cytoskeletal 17 (Cytokeratin-17) (CK-17) (Keratin-17) (K17) (39.1)

KRT17 Gene names

KRT17

Organism

Human

KRT17 Entry name

K1C17_HUMAN

KRT17 Codon optimized cDNA(gene) Clone

KRT17 Cat #

RPE0194

Tag

KRT17 contains A 6x histidine tag

KRT17 Formulation

Liquid

KRT17 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

KRT17 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant KRT17 Protein

KRT17 Cat #

PE0194

KRT17 Source

recombinant

KRT17 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

KRT17 Purity

>90%, as determined by SDS-PAGE under reducing conditions

KRT17 Activity

N/A

Tag

KRT17 Contains A 6x histidine tag

KRT17 Formulation

Liquid

KRT17 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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KRT17 family

Intermediate filament family

KRT17 Subcellular locations

Cytoplasm.

KRT17 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair (By similarity).

KRT17 Sequence

DDBJ

EMBL

GenBank

KRT17 3D structure

ModBase

KRT17 interaction

STRING

KRT17 Proteomic

PRIDE

KRT17 Genome annotation

Ensembl

GeneID

KEGG

UCSC

KRT17 Organism specific

CTD

MGI

KRT17 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

KRT17 Gene expression

Bgee

ArrayExpress

Genevestigator

KRT17 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY