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Human DNA damage-binding protein 2 (aa 1-427)

DDB2 Swiss Prot#

Q92466

DDB2 Protein names

DNA damage-binding protein 2 (Damage-specific DNA-binding protein 2) (DDB p48 subunit) (DDBb) (UV-damaged DNA-binding protein 2) (UV-DDB 2)

DDB2 Gene names

DDB2

Organism

Human

DDB2 Entry name

DDB2_HUMAN

DDB2 Codon optimized cDNA(gene) Clone

DDB2 Cat #

RPE0189

Tag

DDB2 contains A 6x histidine tag

DDB2 Formulation

Liquid

DDB2 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

DDB2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant DDB2 Protein

DDB2 Cat #

PE0189

DDB2 Source

recombinant

DDB2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

DDB2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

DDB2 Activity

N/A

Tag

DDB2 Contains A 6x histidine tag

DDB2 Formulation

Liquid

DDB2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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DDB2 family

WD repeat DDB2/WDR76 family

DDB2 Subcellular locations

Nucleus.

DDB2 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. Isoform D1 and isoform D2 inhibit UV-damaged DNA repair.

DDB2 Sequence

DDBJ

EMBL

GenBank

DDB2 3D structure

ModBase

DDB2 interaction

STRING

DDB2 Proteomic

PRIDE

DDB2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

DDB2 Organism specific

CTD

MGI

DDB2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

DDB2 Gene expression

Bgee

ArrayExpress

Genevestigator

DDB2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY