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Human Angiopoietin-related protein 4 (aa 26-406)

ARP4 Swiss Prot#

Q9BY76

ARP4 Protein names

Angiopoietin-related protein 4 (Angiopoietin-like 4) (Hepatic fibrinogen/angiopoietin-related protein) (HFARP)

ARP4 Gene names

ANGPTL4 (ARP4) (HFARP) (PGAR) (PP1158) (PSEC0166) (UNQ171/PRO197)

Organism

Human

ARP4 Entry name

ANGL4_HUMAN

ARP4 Codon optimized cDNA(gene) Clone

ARP4 Cat #

RPE0169

Tag

ARP4 contains A 6x histidine tag

ARP4 Formulation

Liquid

ARP4 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

ARP4 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant ARP4 Protein

ARP4 Cat #

PE0169

ARP4 Source

recombinant

ARP4 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

ARP4 Purity

>90%, as determined by SDS-PAGE under reducing conditions

ARP4 Activity

N/A

Tag

ARP4 Contains A 6x histidine tag

ARP4 Formulation

Liquid

ARP4 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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ARP4 family

-

ARP4 Subcellular locations

Secreted. Secreted > extracellular space > extracellular matrix.

ARP4 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorgenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation (By similarity).

ARP4 Sequence

DDBJ

EMBL

GenBank

ARP4 3D structure

ModBase

ARP4 interaction

STRING

ARP4 Proteomic

PRIDE

ARP4 Genome annotation

Ensembl

GeneID

KEGG

UCSC

ARP4 Organism specific

CTD

MGI

ARP4 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

ARP4 Gene expression

Bgee

ArrayExpress

Genevestigator

ARP4 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY