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| Human Telomeric repeat-binding factor 2-interacting (aa 2-398) |
| RAP1 Swiss Prot# | | Q9NYB0 |
| RAP1 Protein names | | Telomeric repeat-binding factor 2-interacting protein 1 (TRF2-interacting telomeric protein Rap1) (hRap1) |
| RAP1 Gene names | | TERF2IP (RAP1) (PP8000) |
| Organism | | Human |
| RAP1 Entry name | | TE2IP_HUMAN |
| RAP1 Codon optimized cDNA(gene) Clone |
| RAP1 Cat # | | RPE0166 |
| Tag | | RAP1 contains A 6x histidine tag |
| RAP1 Formulation | | Liquid |
| RAP1 Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| RAP1 Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant RAP1 Protein |
| RAP1 Cat # | | PE0166 |
| RAP1 Source | | recombinant |
| RAP1 Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| RAP1 Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| RAP1 Activity | | N/A |
| Tag | | RAP1 Contains A 6x histidine tag |
| RAP1 Formulation | | Liquid |
| RAP1 Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant RAP1 Products | | For pricing and availability Click Here >>> |
| RAP1 family | | RAP1 family |
| RAP1 Subcellular locations | | Nucleus. Cytoplasm. Chromosome. Chromosome > telomere. |
| RAP1 FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes. |
| RAP1 Sequence | | DDBJ | EMBL | GenBank |
| RAP1 3D structure | | ModBase |
| RAP1 interaction | | STRING |
| RAP1 Proteomic | | PRIDE |
| RAP1 Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| RAP1 Organism specific | | CTD | MGI |
| RAP1 Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| RAP1 Gene expression | | Bgee | ArrayExpress | Genevestigator |
| RAP1 Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
