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| Human Endonuclease VIII-like 1 (aa 2-390) |
| NEIL1 Swiss Prot# | | Q96FI4 |
| NEIL1 Protein names | | Endonuclease VIII-like 1 (Nei-like 1) (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase/AP lyase Neil1) (DNA-(apurinic or apyrimidinic site) lyase Neil1) (NEH1) (FPG1) |
| NEIL1 Gene names | | NEIL1 |
| Organism | | Human |
| NEIL1 Entry name | | NEIL1_HUMAN |
| NEIL1 Codon optimized cDNA(gene) Clone |
| NEIL1 Cat # | | RPE0161 |
| Tag | | NEIL1 contains A 6x histidine tag |
| NEIL1 Formulation | | Liquid |
| NEIL1 Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| NEIL1 Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant NEIL1 Protein |
| NEIL1 Cat # | | PE0161 |
| NEIL1 Source | | recombinant |
| NEIL1 Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| NEIL1 Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| NEIL1 Activity | | N/A |
| Tag | | NEIL1 Contains A 6x histidine tag |
| NEIL1 Formulation | | Liquid |
| NEIL1 Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant NEIL1 Products | | For pricing and availability Click Here >>> |
| NEIL1 family | | FPG family |
| NEIL1 Subcellular locations | | Nucleus. |
| NEIL1 FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. |
| NEIL1 Sequence | | DDBJ | EMBL | GenBank |
| NEIL1 3D structure | | ModBase |
| NEIL1 interaction | | STRING |
| NEIL1 Proteomic | | PRIDE |
| NEIL1 Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| NEIL1 Organism specific | | CTD | MGI |
| NEIL1 Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| NEIL1 Gene expression | | Bgee | ArrayExpress | Genevestigator |
| NEIL1 Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |