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Human Endonuclease VIII-like 1 (aa 2-390)
NEIL1 Swiss Prot#
Q96FI4
NEIL1 Protein names
Endonuclease VIII-like 1 (Nei-like 1) (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase/AP lyase Neil1) (DNA-(apurinic or apyrimidinic site) lyase Neil1) (NEH1) (FPG1)
NEIL1 Gene names
NEIL1
Organism
Human
NEIL1 Entry name
NEIL1_HUMAN
NEIL1 Codon optimized cDNA(gene) Clone
NEIL1 Cat #
RPE0161
Tag
NEIL1 contains A 6x histidine tag
NEIL1 Formulation
Liquid
NEIL1 Storage
Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
NEIL1 Applications
Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant NEIL1 Protein
NEIL1 Cat #
PE0161
NEIL1 Source
recombinant
NEIL1 Applications
Western Blot, SDS-Page or may be used for other applications determined by user
NEIL1 Purity
>90%, as determined by SDS-PAGE under reducing conditions
NEIL1 Activity
N/A
Tag
NEIL1 Contains A 6x histidine tag
NEIL1 Formulation
Liquid
NEIL1 Storage
;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
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NEIL1 family
FPG family
NEIL1 Subcellular locations
Nucleus.
NEIL1 FUNCTION According to UniProtKB Swiss Prot
FUNCTION: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches.
NEIL1 Sequence
DDBJ EMBL GenBank
NEIL1 3D structure
ModBase
NEIL1 interaction
STRING
NEIL1 Proteomic
PRIDE
NEIL1 Genome annotation
Ensembl GeneID KEGG UCSC
NEIL1 Organism specific
CTD MGI
NEIL1 Phylogenomics
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
NEIL1 Gene expression
Bgee ArrayExpress Genevestigator
NEIL1 Family and domain
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY