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Human DNA repair protein RAD51 homolog 3 (aa 1-376)

RAD51L2 Swiss Prot#

O43502

RAD51L2 Protein names

DNA repair protein RAD51 homolog 3 (R51H3) (RAD51-like protein 2)

RAD51L2 Gene names

RAD51C (RAD51L2)

Organism

Human

RAD51L2 Entry name

RA51C_HUMAN

RAD51L2 Codon optimized cDNA(gene) Clone

RAD51L2 Cat #

RPE0153

Tag

RAD51L2 contains A 6x histidine tag

RAD51L2 Formulation

Liquid

RAD51L2 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

RAD51L2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant RAD51L2 Protein

RAD51L2 Cat #

PE0153

RAD51L2 Source

recombinant

RAD51L2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

RAD51L2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

RAD51L2 Activity

N/A

Tag

RAD51L2 Contains A 6x histidine tag

RAD51L2 Formulation

Liquid

RAD51L2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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RAD51L2 family

RecA family, RAD51 subfamily

RAD51L2 Subcellular locations

Nucleus. Cytoplasm. Cytoplasm > perinuclear region. Mitochondrion.

RAD51L2 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. The RAD51B-RAD51C dimer exhibits single-stranded DNA-dependent ATPase activity. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Participates in branch migration and Holliday junction resolution and thus is important for processing HR intermediates late in the DNA repair process. Also has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis.

RAD51L2 Sequence

DDBJ

EMBL

GenBank

RAD51L2 3D structure

ModBase

RAD51L2 interaction

STRING

RAD51L2 Proteomic

PRIDE

RAD51L2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

RAD51L2 Organism specific

CTD

MGI

RAD51L2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

RAD51L2 Gene expression

Bgee

ArrayExpress

Genevestigator

RAD51L2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY