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Human Endonuclease VIII-like 2 (aa 2-332)

NEIL2 Swiss Prot#

Q969S2

NEIL2 Protein names

Endonuclease VIII-like 2 (Nei-like 2) (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase/AP lyase Neil2) (DNA-(apurinic or apyrimidinic site) lyase Neil2) (NEH2)

NEIL2 Gene names

NEIL2

Organism

Human

NEIL2 Entry name

NEIL2_HUMAN

NEIL2 Codon optimized cDNA(gene) Clone

NEIL2 Cat #

RPE0116

Tag

NEIL2 contains A 6x histidine tag

NEIL2 Formulation

Liquid

NEIL2 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

NEIL2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant NEIL2 Protein

NEIL2 Cat #

PE0116

NEIL2 Source

recombinant

NEIL2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

NEIL2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

NEIL2 Activity

N/A

Tag

NEIL2 Contains A 6x histidine tag

NEIL2 Formulation

Liquid

NEIL2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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NEIL2 family

FPG family

NEIL2 Subcellular locations

Nucleus.

NEIL2 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.

NEIL2 Sequence

DDBJ

EMBL

GenBank

NEIL2 3D structure

ModBase

NEIL2 interaction

STRING

NEIL2 Proteomic

PRIDE

NEIL2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

NEIL2 Organism specific

CTD

MGI

NEIL2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

NEIL2 Gene expression

Bgee

ArrayExpress

Genevestigator

NEIL2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY